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In Vitro Toxicology Studies

Computer Modeled Toxicity Prediction

  • Derek is a toxicity prediction software based on an "expert knowledge base"

  • Sarah is a toxicity prediction software built on a "statistical model“

Genotoxicity Assessment

  • Ames

  • Mini-Ames (6-well plate)

  • Chromosomal aberrations in vitro (chamber slides)

  • In vitro binuclear micronucleus (chamber slide/96-well plate)

  • In vitro photogenotoxicity test

  • In vitro multi-biomarker genotoxicity (γ-H2AX, p53, H3, Cleaved-PARP)

Reproductive and Developmental Toxicity Assessment

  • Whole embryo culture in vitro

  • Developmental toxicity screening of zebrafish embryos

Cardiotoxicity Evaluation

  • Cardiac Ion Channel Screening Assay (IC50)

  • hERG potassium channel (HEK293 cells transfected with the hERG gene)

  • Nav1.5 sodium channel (HEK293 cells transfected with Nav1.5 gene)

  • Cav1.2 calcium channel (CHO cells transfected with Cav1.2 gene

  • xCelligence Cardio Analysis System in Real Time

  • Rat primary cardiomyocytes

  • Human induced pluripotent stem cell differentiated cardiomyocytes (hiPSC-CM)

Action Potential Test on Isolated Myocardial Tissue

  • Guinea pig papillary muscle action potential

  • Rabbit Purkinje fiber action potential

  • In vitro evaluation of carcinogenicity

  • Based on the Bhas42-transformed cell system, the cytotoxicity test was used to determine the carcinogenic effect of the compound and the concentration of the growth-promoting test.

  • Based on the Bhas42 transformed cell system, the genes related to the initiation stage and the growth-promoting stage of carcinogenesis were screened by the gene chip method.


  • Chemokines and cytokines changes in immune cell count.

  • T-cell dependent antibody response (TDAR)

  • Immunophenotyping