One Stop ADC Drug Service

Mechanism of Action

Drug Release

The History of ADC Drugs

In Vitro Assays:

Cell cytotoxicity

 Cell killing potency in the breast cancer cell lines KPL-4

Binding specificity and endocytosis assay 

In Vivo ADC Drugs Assays:

Antitumor activity of dual-drug ADCs in tumor model

In vivo efficacy of Zapadcine-1 in acute lymphocyte leukemia mouse CDX models

Evaluation of the in vivo efficacy of Zapadcine-1 in HuKemia® acute lymphocyte leukemia PDX model AL7442

In vivo toxicity of Zapadcine-1

References

1. Perez, Heidi L.; Cardarelli, Pina M.; Deshpande, Shrikant; Gangwar, Sanjeev; Schroeder, Gretchen M.; Vite, Gregory D.; Borzilleri, Robert M. (2014). Antibody–drug conjugates: current status and future directions. Drug Discovery Today, 19(7), 869–881. doi:10.1016/j.drudis.2013.11.004 
   

2. Yamazaki, C.M., Yamaguchi, A., Anami, Y. et al. Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance. Nat Commun 12, 3528 (2021). https://doi.org/10.1038/s41467-021-23793-7